A Statistical Study of the Force Balance and Structure in the Flux Ropes in Mercury’s Magnetotail

This study presents a statistical investigation of the force balance and structures in the flux ropes in Mercury’s magnetotail plasma sheet by using the measurements of MErcury Surface, Space ENviroment, GEochemistry, and Ranging (MESSENGER). One hundred sixty-eight flux ropes were identified from the 14 hot seasons of MESSENGER from 11 March 2011 to 30 April 2015, and 143 of them show clear magnetic field enhancements with the core field being -20% higher than the background magnetic field. The investigation on the force balance of these 143 flux ropes shows that magnetic pressure gradient force cannot be solely balanced by magnetic tension force, implying that thermal plasma pressure gradient force cannot be neglected in the flux ropes. We employ a non-force-free model considering the contribution of thermal pressure to resolve the physical properties of flux ropes in Mercury’s magnetotail. Twenty-eight flux ropes are obtained through the fitting to the non-force-free model. The flux ropes are found to be consistent with the flattened structures, in which the mean semimajor is -851 km and semiminor is -333 km, both are several times the local proton inertial length. The average core field is estimated to be -57.5 nT, and flux content is -0.019 MWb, much larger than the previous results obtained from force-free flux rope model. The importance of thermal pressure gradient in the force balance of the flux ropes and the flattened structure indicates that the flux ropes in Mercury’s magnetotail plasma sheet are mostly in early stage of the evolution, and still contain enough plasma to affect their magnetic structures.Key PointsThermal pressure gradient is significant for the flux ropes in Mercury’s magnetotailNon-force-free modeling reveals the flatten structure and much higher magnetic flux of the flux ropes different from the previous studiesFlux ropes in this study should be in their early stage of evolution and could be strongly affected by thermal pressurePeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151305/1/jgra55044_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151305/2/jgra55044.pd

Stressful first impressions in job interviews

Stress can impact many aspects of our lives, such as the way we interact and work with others, or the first impressions that we make. In the past, stress has been most commonly assessed through self-reported questionnaires; however, advancements in wearable technology have enabled the measurement of physiological symptoms of stress in an unobtrusive manner. Using a dataset of job interviews, we investigate whether first impressions of stress (from annotations) are equivalent to physiological measurements of the electrodermal activity (EDA). We examine the use of automatically extracted nonverbal cues stemming from both the visual and audio modalities, as well EDA stress measurements for the inference of stress impressions obtained from manual annotations. Stress impressions were found to be significantly negatively correlated with hireability ratings i.e individuals who were perceived to be more stressed were more likely to obtained lower hireability scores. The analysis revealed a significant relationship between audio and visual features but low predictability and no significant effects were found for the EDA features. While some nonverbal cues were more clearly related to stress, the physiological cues were less reliable and warrant further investigation into the use of wearable sensors for stress detection

Mutations in noncoding regions of GJB1 are a major cause of X-linked CMT

OBJECTIVE: To determine the prevalence and clinical and genetic characteristics of patients with X-linked Charcot-Marie-Tooth disease (CMT) due to mutations in noncoding regions of the gap junction β-1 gene (GJB1). METHODS: Mutations were identified by bidirectional Sanger sequence analysis of the 595 bases of the upstream promoter region, and 25 bases of the 3′ untranslated region (UTR) sequence in patients in whom mutations in the coding region had been excluded. Clinical and neurophysiologic data were retrospectively collected. RESULTS: Five mutations were detected in 25 individuals from 10 kindreds representing 11.4% of all cases of CMTX1 diagnosed in our neurogenetics laboratory between 1996 and 2016. Four pathogenic mutations, c.-17G>A, c.-17+1G>T, c.-103C>T, and c.-146-90_146-89insT were detected in the 5′UTR. A novel mutation, c.*15C>T, was detected in the 3′ UTR of GJB1 in 2 unrelated families with CMTX1 and is the first pathogenic mutation in the 3′UTR of any myelin-associated CMT gene. Mutations segregated with the phenotype, were at sites predicted to be pathogenic, and were not present in the normal population. CONCLUSIONS: Mutations in noncoding DNA are a major cause of CMTX1 and highlight the importance of mutations in noncoding DNA in human disease. Next-generation sequencing platforms for use in inherited neuropathy should therefore include coverage of these regions

Genetic and clinical characteristics of NEFL-related Charcot-Marie-Tooth disease

OBJECTIVES: To analyse and describe the clinical and genetic spectrum of Charcot-Marie-Tooth disease (CMT) caused by mutations in the neurofilament light polypeptide gene (NEFL). METHODS: Combined analysis of newly identified patients with NEFL-related CMT and all previously reported cases from the literature. RESULTS: Five new unrelated patients with CMT carrying the NEFL mutations P8R and N98S and the novel variant L311P were identified. Combined data from these cases and 62 kindreds from the literature revealed four common mutations (P8R, P22S, N98S and E396K) and three mutational hotspots accounting for 37 (55%) and 50 (75%) kindreds, respectively. Eight patients had de novo mutations. Loss of large-myelinated fibres was a uniform feature in a total of 21 sural nerve biopsies and 'onion bulb' formations and/or thin myelin sheaths were observed in 14 (67%) of them. The neurophysiological phenotype was broad but most patients with E90K and N98S had upper limb motor conduction velocities <38 m/s. Age of onset was ≤3 years in 25 cases. Pyramidal tract signs were described in 13 patients and 7 patients were initially diagnosed with or tested for inherited ataxia. Patients with E90K and N98S frequently presented before age 3 years and developed hearing loss or other neurological features including ataxia and/or cerebellar atrophy on brain MRI. CONCLUSIONS: NEFL-related CMT is clinically and genetically heterogeneous. Based on this study, however, we propose mutational hotspots and relevant clinical-genetic associations that may be helpful in the evaluation of NEFL sequence variants and the differential diagnosis with other forms of CMT

Current progress on removal of recalcitrance coloured particles from anaerobically treated effluent using coagulation–flocculation

The palm oil industry is the most important agro industries in Malaysia and most of the mills adopt anaerobic digestion as their primary treatment for palm oil mill effluent (POME). Due to the public concern, decolourisation of anaerobically treated POME (AnPOME) is becoming a great concern. Presence of recalcitrant-coloured particles hinders biological processes and coagulation–flocculation may able to remove these coloured particles. Several types of inorganic and polymers-based coagulant/flocculant aids for coagulation–flocculation of AnPOME have been reviewed. Researchers are currently interested in using natural coagulant and flocculant aids. Modification of the properties of natural coagulant and flocculant aids enhanced coagulation–flocculation performance. Modelling and optimization of the coagulation–flocculation process have also been reviewed. Chemical sludge has the potential for plant growth that can be evaluated through pot trials and phytotoxicity test

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

Objective: Gastric cancer is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. This study sought to identify the most prevalent molecular targets in gastric cancer and to elucidate systematic patterns of exclusivity and co-occurrence among these targets, through comprehensive genomic analysis of a large panel of gastric cancers. Design: Using high-resolution single nucleotide polymorphism arrays, copy number alterations were profiled in a panel of 233 gastric cancers (193 primary tumours, 40 cell lines) and 98 primary matched gastric non-malignant samples. For selected alterations, their impact on gene expression and clinical outcome were evaluated. Results: 22 recurrent focal alterations (13 amplifications and nine deletions) were identified. These included both known targets (FGFR2, ERBB2) and also novel genes in gastric cancer (KLF5, GATA6). Receptor tyrosine kinase (RTK)/RAS alterations were found to be frequent in gastric cancer. This study also demonstrates, for the first time, that these alterations occur in a mutually exclusive fashion, with KRAS gene amplifications highlighting a clinically relevant but previously underappreciated gastric cancer subgroup. FGFR2-amplified gastric cancers were also shown to be sensitive to dovitinib, an orally bioavailable FGFR/VEGFR targeting agent, potentially representing a subtype-specific therapy for FGFR2-amplified gastric cancers. Conclusion: The study demonstrates the existence of five distinct gastric cancer patient subgroups, defined by the signature genomic alterations FGFR2 (9% of tumours), KRAS (9%), EGFR (8%), ERBB2 (7%) and MET (4%). Collectively, these subgroups suggest that at least 37% of gastric cancer patients may be potentially treatable by RTK/RAS directed therapies

3D Magnetic Reconnection with a spatially confined X-line extent -- Implications for Dipolarizing Flux Bundles and the Dawn-Dusk Asymmetry

Using 3D particle-in-cell (PIC) simulations, we study magnetic reconnection with the x-line being spatially confined in the current direction. We include thick current layers to prevent reconnection at two ends of a thin current sheet that has a thickness on an ion inertial (di) scale. The reconnection rate and outflow speed drop significantly when the extent of the thin current sheet in the current direction is < O(10 di). When the thin current sheet extent is long enough, we find it consists of two distinct regions; an inactive region (on the ion-drifting side) exists adjacent to the active region where reconnection proceeds normally as in a 2D case. The extent of this inactive region is ~ O(10 di), and it suppresses reconnection when the thin current sheet extent is comparable or shorter. The time-scale of current sheet thinning toward fast reconnection can be translated into the spatial-scale of this inactive region; because electron drifts inside the ion diffusion region transport the reconnected magnetic flux, that drives outflows and furthers the current sheet thinning, away from this region. This is a consequence of the Hall effect in 3D. While this inactive region may explain the shortest possible azimuthal extent of dipolarizing flux bundles at Earth, it may also explain the dawn-dusk asymmetry observed at the magnetotail of Mercury, that has a global dawn-dusk extent much shorter than that of Earth.Comment: 9 pages, 9 figures, submitted to JGR on 01/23/201

Tumor Biomarker Glycoproteins in the Seminal Plasma of Healthy Human Males Are Endogenous Ligands for DC-SIGN

Published online 2011 October 10. doi: 10.1074/mcp.M111.008730DC-SIGN is an immune C-type lectin that is expressed on both immature and mature dendritic cells associated with peripheral and lymphoid tissues in humans. It is a pattern recognition receptor that binds to several pathogens including HIV-1, Ebola virus, Mycobacterium tuberculosis, Candida albicans, Helicobacter pylori, and Schistosoma mansoni. Evidence is now mounting that DC-SIGN also recognizes endogenous glycoproteins, and that such interactions play a major role in maintaining immune homeostasis in humans and mice. Autoantigens (neoantigens) are produced for the first time in the human testes and other organs of the male urogenital tract under androgenic stimulus during puberty. Such antigens trigger autoimmune orchitis if the immune response is not tightly regulated within this system. Endogenous ligands for DC-SIGN could play a role in modulating such responses